Identification of Long-Term Repopulating Potential of Human Cord Blood-Derived CD34−flt3−Severe Combined Immunodeficiency-Repopulating Cells by Intra-Bone Marrow Injection
نویسندگان
چکیده
منابع مشابه
SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection.
Precise analysis of human CD34-negative (CD34(-)) hematopoietic stem cells (HSCs) has been hindered by the lack of a simple and reliable assay system of these rare cells. Here, we successfully identify human cord blood-derived CD34(-) severe combined immunodeficiency (SCID)- repopulating cells (SRCs) with extensive lymphoid and myeloid repopulating ability using the intra-bone marrow injection ...
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Severe combined immunodeficient (SCID)-repopulating cells (termed SRC) with lymphohaematopoietic differentiation potential reside at an extremely low frequency in unmobilised adult human peripheral blood. Recently, an ex vivo method of increasing the relative numbers of at least four distinct human stem cell classes, that include CD34+ haematopoietic progenitor cells, in mononuclear cells (MNC)...
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ژورنال
عنوان ژورنال: Stem Cells
سال: 2007
ISSN: 1066-5099,1549-4918
DOI: 10.1634/stemcells.2006-0727